Results
| PMID | 22537218 |
| Gene Name | CASP1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 85 |
| Population details | 85 women with and without endometriosis |
| Sex | Female |
| Associated genes | IL-1beta, IL-18 and ICE |
| Other associated phenotypes |
Endometriosis |
|
Am J Reprod Immunol. 2012 Aug;68(2):138-45. doi: Sikora, Justyna| Mielczarek-Palacz, Aleksandra| Kondera-Anasz, Zdzislawa Department of Immunology and Serology, Medical University of Silesia, Katowice, Poland. sikoraj@poczta.onet.pl PROBLEM: To assess whether interleukin (IL)-1beta, IL-18 and interleukin-1 converting enzyme (ICE) are involved in the pathogenesis of endometriosis. METHOD OF STUDY: Peritoneal fluid (PF) was obtained from 85 women with and without endometriosis. Peritoneal macrophages were cultured and the culture media collected. IL-1beta, IL-18 and ICE levels were measured by the enzyme-linked immunosorbent assay (ELISA). RESULTS: Levels of IL-1beta and ICE in PF of women with endometriosis were higher than those in the control group. However, PF level of IL-18 was significantly lower in the study group than in the controls. Higher secretion of IL-1beta by peritoneal macrophages and lower IL-18 and ICE in endometriosis patients than in control were observed. Following lipopolysaccharide (LPS) stimulation, the macrophages secreted more IL-1beta, IL-18 and ICE in all groups. CONCLUSIONS: The results pointed to impairment of the secretion of the IL-1 cytokine family in endometriosis. Invalid IL-1beta and IL-18 maturation by ICE may be an important pathogenic factor in endometriosis. Mesh Terms: Adult| Caspase 1/genetics/*metabolism| Cells, Cultured| Endometriosis/*immunology| Enzyme-Linked Immunosorbent Assay| Female| Gene Expression Regulation/immunology| Humans| Interleukin-18/genetics/*metabolism| Interleukin-1beta/genetics/*metaboli |
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